Drug Generalized Hypersensitivity Reactions to Tolperisone (Mydocalm)

Andrzej Chcialowski, Aleksander Zakrzewski and Jerzy Kruszewski

Department of Infectious Diseases and Allergology, Military Institute of Medicine, Poland

^*Correspondance to: Andrzej Chcialowski 

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Abstract:

Tolperizol (Mydocalm) is a widely used drug as a skeletal muscle relaxant and is often additionally prescribed by family doctors in the course of lumbar discopathy. Among its adverse event, the possibility of a hypersensitivity reaction to anaphylactic shock is also mentioned. Few cases of severe hypersensitivity to this drug in the literature as now have been reported. Two cases of anaphylactic hypersensitivity and its confirmation using an oral challenge test are presented. These cases should draw the attention of GP doctors to the possibility of hypersensitivity to tolperizol. They also emphasize the need to pay particular attention to the patients’ medical history of prodromal symptoms such as pruritis and urticaria, which may predict the occurrence of more severe general reactions.

Keywords:

Tolperisone; Drugs; Hypersensitivity reaction; Anaphylactic shock

Cite the Article:

Chcialowski A, Zakrzewski A, Kruszewski J. Drug Generalized Hypersensitivity Reactions to Tolperisone (Mydocalm). Clin Case Rep Int. 2018; 2: 1036.