Journal Basic Info

  • Impact Factor: 0.285**
  • H-Index: 6
  • ISSN: 2638-4558
  • DOI: 10.25107/2638-4558
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Breast Neoplasms
  •  Preventive Medicine
  •  ENT
  •  Epidemiology
  •  Mental Health
  •  Food Science
  •  Dermatology and Cosmetology
  •  Traumatology

Abstract

Citation: Clin Case Rep Int. 2019;3(1):1109.DOI: 10.25107/2638-4558.1109

Aggressive Metastatic Breast Cancer to the Placenta Causing Placental Abruption

Smith W and Smith K

Department of Internal Medicine, University of South Carolina, USADepartment of Obstetrics and Gynecology, University of South Carolina, USA

*Correspondance to: Wesley Smith 

 PDF  Full Text Case Report | Open Access

Abstract:

Background: The incidence of breast cancer in young women is increasing and will likely affect more pregnancies as women continue to delay childbirth. Metastasis to the placenta is an uncommon finding in pregnant women, and there is only one reported case causing placental abruption, which involved a cancer of unknown primary. Triple-negative breast cancers tend to be more aggressive overall and have a worse prognosis. Results: A 35-year-old Hispanic woman was diagnosed at 24 weeks gestation with widely metastatic triple-negative breast cancer to the lungs, liver, peritoneum, lymph nodes, and thoracic spine. Chemotherapy was subsequently started with carboplatin and paclitaxel. She was induced at 36 weeks and had a placental abruption despite lacking significant risk factors. Pathology of the placenta revealed intervillous malignant cells consistent with the placental spread of cancer. Conclusion: Breast cancer in pregnancy can be difficult to manage regarding therapy options and timing of therapy. Chemotherapy after the first trimester is relatively safe to mother and fetus. However, common agents like trastuzumab and tamoxifen are not recommended due to their teratogenic effects. Pregnancy itself does not increase the risk of mortality in breast cancer; however, diagnosis and treatment are delayed, and pregnant women are more commonly diagnosed with advanced stages of cancer compared to their non-pregnant counterparts. Although placental involvement of cancer is rare, it relays a poor prognosis, and any underlies the importance of placental micro examination in all women with known cancer.

Keywords:

Metastasis; Chemotherapy; Breast cancer

Cite the Article:

Smith W, Smith K. Aggressive Metastatic Breast Cancer to the Placenta Causing Placental Abruption. Clin Case Rep Int. 2019; 3: 1109. .

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