Mineral and Bone Disorders in Chronic Hemodialysis and Evaluation of Adherence to the KDIGO 2017 Recommendation: Multicenter Study of 658 Patients

Ezzaki S, Failal I, Mtioui N, Khayat S, Zamed M, Medkouri G, Benghanem M and Ramdani B

Department of Nephrology, Hemodialysis and Kidney Transplantation, CHU Ibn Rochd, Casablanca, Morocco

^*Correspondance to: Ezzaki S 

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Abstract:

Introduction: Phosphocalcic metabolism disorders are frequent in chronic hemodialysis; their clinical complications and their impact on the vital prognosis justify appropriate prevention and treatment. Our objective is to determine the phosphocalcic status and the prevalence of BMD in our hemodialysis patients and to assess the degree of adherence to the KDIGO 2017 recommendations.
Methods: We conducted a retrospective multicenter study in the… region, including 658 hemodialysis patients.
Results: Bone pain was present in 47.6% of patients. 15.6% of patients suffering from pruritus, while 24.3% of patients had conjunctivitis. Biologically, the mean serum calcium was 87.77 mg/l, the average serum phosphorus was 46.85 mg/l, the average PTH was 489.29 pg/ml. Therapeutically, calcium supplementation was prescribed in 78.8% of the cases, 30.5% of patients received the derivatives of vitamin D, of phosphorus chelators without calcium were prescribed in 15% of patients, 5% of patients were treated with a calcimimetic. And 7% by parathyroidectomy.
The average age of our patients was 49 ± 14.6 years, with a male predominance, the causal nephropathy was undetermined in 48.3%, the average duration of hemodialysis was 85 ± 54 months. Bone pain was present in 47.6% of patients. 15.6% of the patients suffered from pruritus, while 24.3% of the patients had conjunctivitis. Biologically, The mean calcemia was 87.77 mg/l, the
mean phosphatemia was 46.85 mg/l, The mean PTH was 489.29 pg/ml. Therapeutically, calcium supplementation was prescribed in 78.8% of the cases, 30.5% of the patients received the derivatives of vitamin D, phosphorus binders were prescribed in 15% of the patients, 5% of the patients were treated with a calcimimetic. And 7% by parathyroidectomy. The 3 targets recommended by the KDIGOs were achieved in only 29.3% of patients.

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Cite the Article:

Ezzaki S, Failal I, Mtioui N, Khayat S, Zamed M, Medkouri G, et al. Mineral and Bone Disorders in
Chronic Hemodialysis and Evaluation of Adherence to the KDIGO 2017 Recommendation: Multicenter Study of
658 Patients. Clin Case Rep Int. 2021;5:1228..