Journal Basic Info

  • Impact Factor: 0.285**
  • H-Index: 6
  • ISSN: 2638-4558
  • DOI: 10.25107/2638-4558
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Endocrinology
  •  Anatomy
  •  Oncology
  •  Pediatrics
  •  Palliative Care
  •  Physiology
  •  Epilepsy and Seizures
  •  Genetics

Abstract

Citation: Clin Case Rep Int. 2022;6(1):1271.DOI: 10.25107/2638-4558.1271

Complete Response of a Leptomeningeal and Brain Relapse Following Treatment with Pertuzumab Plus Trastuzumab Plus Paclitaxel of a HER2 Positive Breast Cancer

Borrego Manuel Ruiz and Carlos Torrado Martin

Virgen del Rocío University Hospital, Spain

*Correspondance to: Borrego Manuel Ruiz 

 PDF  Full Text Case Report | Open Access

Abstract:

Central nervous system and leptomeningeal disease due to HER2-positive breast cancer has limited treatment options and poor prognosis. A 67-year-old female previously treated because of a localized HER2-positive breast cancer presented to the Emergency Department in December 2019 due to a 3-month history of worsening headaches and diminished sensation in the left facial area. A Magnetic resonance of the brain demonstrated four intracranial lesions and leptomeningeal disease suggestive of disseminated disease. Pertuzumab 840 mg IV day 1 followed by 420 mg and trastuzumab 8 mg/kg IV on day 1 followed by 6 mg/kg IV cycled every 21 days, and weekly paclitaxel 75 mg/m2 IV was performed for 9 months. Clinical and radiological response was achieved and maintained for more than 34 months.

Keywords:

Cite the Article:

Ruiz BM, Martin CT. Complete Response of a Leptomeningeal and Brain Relapse Following Treatment with Pertuzumab Plus Trastuzumab Plus Paclitaxel of a HER2 Positive Breast Cancer. Clin Case Rep Int. 2022; 6: 1271.

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