Roberto Yunes1#, Claudia Bregonzio2*#, Vanina Villegas1, Belén Mulle1 and Ricardo Cabrera1
1Biomedical Research Institute (INBIOMED-IMBECU-CONICET), University of Mendoza, Argentina
2Department of Pharmacology, Institute of Experimental Pharmacology Córdoba (IFEC-CONICET), National
University of Córdoba, Argentina
#These authors contributed equally to this work
Parkinson’s disease is a common neurodegenerative disorder, second only to Alzheimer's disease. It has been the object of growing interest since its frequency tends to augment as life expectancy has increased globally considered. In this work, we study the eventual neuroprotective effect of Progesterone (P4) injected a few days before establishing a Reserpine (R) model of Parkinsonism in adult male rats. We focused on cognitive (Novel Object Recognition test; NOR), affective (Forced Swimming Task; FST) and motor (Catalepsy Test; CT) outputs. We performed the appropriate tests along with the administration for two weeks of low doses of R. Our results show very clearly that P4 prevents the impairment of several tasks regarding the deleterious effects of R, without affecting negatively other areas of the subject behavior. In total accordance with current information, we show here that P4 -in particular- and neuroactive steroids -in general- are promising molecules to delay diverse manifestations of neurotransmitters depletion.
Progesterone; Neuroactive steroids; Parkinsonism; Neuroprotection; Male rats
Yunes R, Bregonzio C, Villegas V, Mulle B, Cabrera R. Progesterone Prevents Impairment of Cognitive, Affective and Motor Events in a Reserpine Model of Parkinsonism in Male Rats. Clin Case Rep Int. 2022; 6: 1321..