Yayoi Yamamoto1*, Toshinari Yamashita2, Kota Washimi3 and Hiroaki Kurihara1
1Department of Diagnostic and Interventional Radiology, Kanagawa Cancer Center, Japan
2Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Japan
3Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan
A novel digital PET/CT system has improved image quality to detect small lesions compared with conventional OSEM-based reconstruction. As for breast cancer, the evaluation of the primary site has been limited in conventional PET/CT due to its low sensitivity and specificity. The novel digital PET/CT system has been shown to increase the detection and visualization of internal properties for breast cancer due to its higher spatial resolution. Here we report a case of 56-year-old woman with right-sided breast cancer in which heterogeneous 18F-FDG accumulation demonstrated on digital PET/CT system. She presented to our medical center with a palpable mass in her right breast. She had no previous or family history of breast or ovarian cancer. The PET images showed marked focal 18F-FDG uptake in the upper inner aspect of the right breast with heterogeneous intratumoral 18F-FDG accumulation. The clinical staging was T2N1M0 Stage II. Right modified radical mastectomy was performed. Numerous tumor cells identified histopathologically with hematoxylin and eosin staining matched the site of marked 18F-FDG accumulation on the PET images, and fibrotic or cystic sites with fewer tumor cells matched sites of 18F-FDG hypo-accumulation. A novel digital PET/CT images enabled evaluation of internal cellular properties that may be related to prediction of prognosis.
Yamamoto Y, Yamashita T, Washimi K, Kurihara H. A Case Report Evaluated the Internal Properties of a Breast Cancer Lesion Using Digital PET/CT. Clin Case Rep Int. 2022; 6: 1340.