Waltener M1, Hanseeuw B2,3,4, Benjamin L5, Hugues J5 and Sibille FX6,7*
1Department of Neurology, CHU UCL Namur, Belgium
2Department of Neurology, Saint-Luc University Clinics, Belgium
3Department of Neuroscience, University in Ottignies-Louvain-la-Neuve, Belgium
4Department of Radiology, Massachusetts General Hospital, USA
5Department of Clinical Biology, CHU UCL Namur, Belgium
6Department of Geriatric Medicine, CHU UCL Namur, Belgium
7Institute Health and Society, UCLouvain, Belgium
Background: Lymphomatosis cerebri (LC) is a rare variant of Primary Central Nervous System Lymphoma (PCNSL). This unusual presentation differs from systemic lymphoma or intravascular CNS lymphoma. It is often misdiagnosed, leading to delayed diagnosis and treatment. As the literature contains only case reports and small case series, it has not been adequately characterized. Case Report: We present the history of an 85-year-old man with a recent history of bilateral facial palsy. He was admitted with a rapidly progressive cognitive impairment not consistent with delirium. Diagnosis of LC was based on magnetic resonance imaging and cerebrospinal fluid analysis. Due to the patient’s poor health status, biopsy was not performed. He passed away two weeks later. Conclusion: To avoid misdiagnosis and delayed treatment of LC, multiple CSF analysis should be performed.
Lymphomatosis cerebri; Cognitive decline; Facial palsy
Waltener M, Hanseeuw B, Benjamin L, Hugues J, Sibille FX. Bilateral Facial Palsy and Rapid Cognitive Decline Indicating Lymphomatosis cerebri: A Case Report. Clin Case Rep Int. 2022; 6: 1383.