Clin Case Rep Int | Volume 6, Issue 1 | Case Report | Open Access

Mismatch Repair Status Analysis on Endometrial Biopsy as a Predictor of Endometrial Cancer Behavior in Fertility Sparing Treated Women

Capasso I1,2, Perrone E1*, Scambia G1,2 and Fanfani F1,2

1Department for Women's and Child Health and Public Health, A. Gemelli University Hospital Foundation, Italy
2Catholic University of Sacred Heart, Italy

*Correspondance to: Emanuele Perrone 

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Abstract

Conservative management for patients with mucosal-confined endometrial cancer is a safe approach. Due to the latest evidences, endometrial cancer molecular characterization results crucial for proper risk stratification. A young woman with G1 endometrioid endometrial cancer diagnosed by hysteroscopy was treated conservatively. After cancer persistence, she underwent radical surgery for advanced disease. Posthoc immunohistochemical analysis was performed comparing the first-diagnosis biopsy (mismatch repair deficiency) to surgical specimen (mismatch repair proficiency). Interestingly, not only the cancer changed biochemically, but it also shifted from a confined tumor to an advanced disease with bulky lymph nodes and negative endometrial infiltration. Eventually, the patient was diagnosed with Lynch syndrome. A wiser evaluation of the mismatch repair deficiency should have guided to the proper therapeutic algorithm, also suggesting genetic tests. This case report represents an encouragement to further investigations on molecular assessment as a predictor for endometrial cancer risk stratification in conservative management.

Keywords:

Cancer; Endometrium; Fertility; Genital Neoplasms; Immunohistochemistry

Citation:

Capasso I, Perrone E, Scambia G, Fanfani F. Mismatch Repair Status Analysis on Endometrial Biopsy as a Predictor of Endometrial Cancer Behavior in Fertility Sparing Treated Women. Clin Case Rep Int. 2022; 6: 1389.

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