Rosa Maria Rios-Pelegrina*, Javier L Lopez-Hidalgo, Javier Urrutia and Alexandra J Remon
San Cecilio Hospital, Knowledge Avenue S/N, Granada, SpainFulltext PDF
Metaplastic changes from urothelium to intestinal type epithelium in the renal pelvis are rare and have the potential of undergoing a malignant transformation to adenocarcinoma. We report a case of intestinal metaplasia in pyelocaliceal and urothelial systems associated to squamous metaplasia without residual urothelium, in a 73-year-old female patient’s right kidney, associated with pyelocaliceal lithiasis, and without malignant transformation. The patient underwent a nephroureterectomy. The metaplastic epithelium’s immunohistochemistry shows positivity to cytokeratin 20, low Ki-67 index, and a lack of expression of p53. In this case, terminal renal illness with the aforementioned metaplastic changes didn’t evolve towards adenocarcinoma, which indicates that intestinal metaplasia doesn’t always imply malignant transformation.
Rios-Pelegrina RM, Lopez-Hidalgo JL, Urrutia J, Remon AJ. Intestinal Type Metaplasia in Renal Pelvis. Clin Case Rep Int. 2022; 6: 1407.