Journal Basic Info

  • Impact Factor: 0.285**
  • H-Index: 6
  • ISSN: 2638-4558
  • DOI: 10.25107/2638-4558
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Family Medicine and Public Health
  •  Anesthesiology and Pain Medicine
  •  Urology Cases
  •  Cancer Clinic
  •  Nutrition and Dietetics
  •  Dentistry and Oral Medicine
  •  Psychiatry
  •  Pulmonary Disease


Citation: Clin Case Rep Int. 2017;1(1):1008.DOI: 10.25107/2638-4558.1008

An Aggressive Small Round Blue Malignancy in the Intensive Care Unit

Loh CH, Tan SH and Tee KH

Department of Respiratory & Critical Care Medicine, Changi General Hospital, Singapore

*Correspondance to: Loh CH 

 PDF  Full Text Case Report | Open Access


Ewing sarcoma family of tumors is highly aggressive, with common local recurrence and distant metastases. Histologically they appear as small round blue cells, but this is nonspecific with broad differentials. The ESWR1 break-apart rearrangement using fluorescence in-situ hybridization is pathognomonic for Ewing’s sarcoma. Patients with extra skeletal Ewing sarcoma family have a poor prognosis, with median survival ranging between 8 to 15 months in two different case series. Among patients with cancer, approximately 5% develop a critical illness requiring intensive care unit (ICU) admission. We report a case of a young female who developed acute respiratory failure secondary to this rare malignancy that required intensive care treatment. Unlike other reported cases, our patient had a large lung and mediastinal mass with pleura but no bony involvement, associated massive pleural effusion necessitating chest tube insertion, subsequent intensive care admission with invasive ventilatory support. This case highlights the importance of supportive intensive care needed to treat this aggressive disease mainly affecting children and young adults.


Cite the Article:

Loh CH, Tan SH, Tee KH. An Aggressive Small Round Blue Malignancy in the Intensive Care Unit. Clin Case Rep Int. 2017; 1: 1008.

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