Leptomeningeal Metastasis in Non-Small Cell Lung Cancer: A Report of Two Cases and Short Rewiev of Literature

Pinar Akın Kabalak, Derya Kizilgoz, Tuba Inal Cengiz, Ulku Yilmaz, Sebnem Yucel and Suzan Biri

Department of Chest Disease, Ankara Atatürk Chest Disease and Thoracic Surgery Training and Research Hospital, Turkey Department of Medical Oncology, Ankara Atatürk Chest Disease and Thoracic Surgery Training and Research Hospital, Turkey Department of Radiology, Ankara Atatürk Chest Disease and Thoracic Surgery Training and Research Hospital, Turkey

^*Correspondance to: Pinar Akin Kabalak 

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Abstract:

Central Nervous System (CNS) metastasis cause serious clinical deterioration in patient with NonSmall Cell Lung Cancer (NSCLC). Systemic cytotoxic agents, Whole Brain Irradiation (WBRT), oral targeted therapies and Intrathecal Chemotherapy (IC) are well known treatment options. In first case we aim to share two lung cancer patients at young ages with Leptomeningeal Metastasis (LM) treated with oral targeted therapies combined with WBRT.

Keywords:

Non-small cell lung cancer; Leptomeningeal metastasis; Neuroimaging; Epidermal growth factor receptor tyrosine kinase inhibitors; ALK inhibitor

Cite the Article:

Kabalak PA, Kızılgöz D, Cengiz Tİ, Yılmaz Ü, Yücel Ş, Biri S. Leptomeningeal Metastasis in NonSmall Cell Lung Cancer: A Report of Two Cases and Short Rewiev of Literature. Clin Case Rep Int. 2017; 1: 1023.