Journal Basic Info

  • Impact Factor: 0.285**
  • H-Index: 6
  • ISSN: 2638-4558
  • DOI: 10.25107/2638-4558
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Cardio-Thoracic Surgery
  •  Tuberculosis
  •  Physical Medicine & Rehabilitation
  •  Child Birth
  •  ENT
  •  Allergy & Immunology
  •  Otolaryngology
  •  Inflammation

Abstract

Citation: Clin Case Rep Int. 2020;4(1):1171.DOI: 10.25107/2638-4558.1171

A Case Report of Primary CNS Lymphoma of Choroid Plexus

Mastura Monif, Michael Christie, Mark Marriott, Katherine J Drummond and Lynette Chee

Department of Neurology, Royal Melbourne Hospital, Australia Department of Pathology, Royal Melbourne Hospital, Australia Department of Neurosurgery, Royal Melbourne Hospital, Australia Department of Clinical Hematology and BMT Service, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Australia Department of Physiology, The University of Melbourne, Australia Department of Neuroscience, Monash University, Australia

*Correspondance to: Mastura Monif 

 PDF  Full Text Case Report | Open Access

Abstract:

Primary CNS Lymphoma (PCNSL) of the choroid plexus is a very rare tumor. Its clinical and radiological manifestations are not entirely clear due to the rarity of the disease; and hence diagnosis of this condition can be delayed due lack of knowledge associated with the disease. We present a case of a 63-year-old man who presented with a few weeks of cognitive deficits with dysphasia and marked impairments in short term memory. His MRI brain showed subtle FLAIR and T1 contrast abnormalities near the lateral ventricles abutting the temporal lobe at the choroid plexus. On brain biopsy he was noted to have perivascular atypical B lymphocytes consistent with PCNSL. High-dose methotrexate, teniposide, BCNU, prednisolone and Rituximab, followed by 5 months of consolidative chemotherapy with cytarabine resulted in clinical and radiological improvement. He subsequently relapsed twice and salvage chemotherapy with consolidative radiotherapy was delivered. Unfortunately, 6 months later his condition worsened and he was referred to palliative care, and then deceased. PCNSL of the choroid plexus is very rare and cases of relapsed disease generally have poor outcome despite a variety of chemo and radiotherapy options. Targeted therapies with optimal penetration of the blood brain barrier are warranted.

Keywords:

Primary CNS lymphoma; Choroid plexus; Brain malignancy

Cite the Article:

Monif M, Christie M, Marriott M, Drummond KJ, Chee L. A Case Report of Primary CNS Lymphoma of Choroid Plexus. Clin Case Rep Int. 2020; 4: 1171.

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