The Development of De novo Acute Tubulointerstitial Nephritis and Membranous Nephropathy Following Inactivated COVID-19 Vaccine: Causal or Casual?

Zhao Y, Zhang L, Wang G, Guan J and Pai P

Department of Microbiology, The University of Hong Kong-Faculty of Medicine, China
Department of Nephrology, The University of Hong Kong-Shenzhen Hospital, China
Department of Pathology, The University of Hong Kong-Shenzhen Hospital, China
Department of Medicine, The University of Hong Kong-Faculty of Medicine, China
Both the authors contributed equally to this work

^*Correspondance to: Pearl Pai 

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Abstract:

Acute tubulointerstitial nephritis is a common cause of hospital acquired acute kidney injury as part of a drug reaction, for instance after β-lactam antibiotics. Different types of COVID-19 vaccineassociated kidney diseases have been reported mostly following mRNA vaccine. The underlying mechanism remains unclear. Recently we treated 3 patients who developed acute tubulointerstitial nephritis and membranous nephropathy following COVID-2019 inactivated vaccine. We wish to share with others these potentially rare conditions and offer our experience in treatment.

Keywords:

Coronavirus disease 2019; Inactivated vaccine; Membranous nephropathy; Acute tubulointerstitial nephritis

Cite the Article:

Zhao Y, Zhang L, Wang G, Guan J, Pai P. The Development of De novo Acute Tubulointerstitial Nephritis and Membranous Nephropathy Following Inactivated COVID-19 Vaccine: Causal or Casual?. Clin Case Rep Int. 2022; 6: 1344.