Constitutional Syndrome: First Case Reported as a Debut of Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome

Núñez-Cruz JM, Casanova-Rama A, López-Brotons M, Milla-Olaya B, Martín-Benlloch S, Brotons-Bañón E, Seguí-Pérez C, López-Corbalán JC, Seguí-Pérez M, Martínez-Caballero A, Orozco-Beltrán D and Seguí-Ripoll JM

Internal Medicine Service, San Juan University Hospital, Spain
Department of Clinical Medicine, Medical School, University Miguel Hernández de Elche, Spain
Government Sub-delegation, Alicante Immunization Center, Spain
Veterinary School, University Cardenal Herrera, Spain
Nuclear Medicine Service, San Juan University Hospital, Spain
School of the Marist Brothers of Alicante, Spain
Primary Care Medicine, Cabo Huertas Health Center, Spain

^*Correspondance to: Seguí-Ripoll JM 

 PDF  Full Text Case Report | Open Access

Abstract:

SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a rare, heterogeneous, chronic autoinflammatory disease characterized by dermatological and osteoarticular clinical manifestations affecting multiple regions. Systemic manifestations are rare. We present the case of a middle-aged man with polyarthralgia and constitutional syndrome under study. He underwent diagnostic imaging tests that helped establish the differential diagnosis as SAPHO syndrome without skin involvement. To our knowledge, this is the first reported case of SAPHO syndrome that debuted as a constitutional condition, and this syndrome should be considered in the diagnostic spectrum.

Keywords:

#

Cite the Article:

Núñez-Cruz JM, Casanova-Rama A, López-Brotons M, Milla-Olaya B, Martín-Benlloch S, Brotons-Bañón E, et al. Constitutional Syndrome: First Case Reported as a Debut of Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome. Clin Case Rep Int. 2023; 7: 1457.