Fatal Human Herpesvirus-6 Infection Following CD45RA T Cell-Depleted Fully Matched Unrelated Donor Hematopoietic Stem Cell Transplantation

Morillas M, Español I, Blanquer M, Torchia M, Sánchez-Villalobos M, Poveda A, Sánchez-Salinas A and Moraleda JM

Department of Hematology, University Hospital of Alicante, Spain
Department of Hematology, University Hospital Virgen de la Arrixaca, IMIB-Pascual Parrilla, University of Murcia, Spain

^*Correspondance to: Ignacio Español 

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Abstract:

T cell-depleted grafts may increase fungal and viral infections following allogeneic Hematopoietic Stem Cell Transplantation (HSCT). A severe human herpesvirus-6 infection was detected after a CD45RA T cell-depleted fully matched unrelated donor HSCT for an adult patient with B-cell acute lymphoblastic leukemia with t(9;22) (q34.1;q11.2). Despite combined treatment with ganciclovir and foscarnet, a rapid multi-organ failure set in and was fatal.

Keywords:

Human herpesvirus-6; CD45 RA T-cell depletion; Matched unrelated donor; Hematopoietic stem cell transplantation; B-cell acute lymphoblastic leukemia

Cite the Article:

Morillas M, Español I, Blanquer M, Torchia M, Sánchez-Villalobos M, Poveda A, et al. Fatal Human Herpesvirus-6 Infection Following CD45RA T Cell-Depleted Fully Matched Unrelated Donor Hematopoietic Stem Cell Transplantation. Clin Case Rep Int. 2023; 7: 1501.