Clin Case Rep Int | Volume 7, Issue 1 | Case Report | Open Access

Vogt-Koyanagi-Harada Disease Recurred after 8 Days of Initial Steroid Pulse Therapy: A Case Report

Muto T1,2*, Sakamoto M1, Machida S1 and Imaizumi S2

1Dokkyo Medical University Saitama Medical Center, Japan
2Imaizumi Eye Hospital, Japan

*Correspondance to: Tetsuya Muto 

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Purpose: This study aimed to report a case of Vogt-Koyanagi-Harada (VKH) disease that recurred 8 days after initial pulsed corticosteroid therapy, which is quite short. Case and Findings: A 56-year-old male patient presented with blurred vision in both eyes and a headache for 6 days. His best-corrected visual acuity was 1.2 and 0.7 in the right and left eye, respectively. A serous retinal detachment in the posterior fundus was observed in both eyes. He was diagnosed with VKH disease. Fundus fluorescein angiography revealed multiple pinpoint leaks suggestive of VKH disease. He received 1000 mg of daily methylprednisolone infusion, for 3 days, followed by oral prednisolone, at 40 mg daily. Serous retinal detachment and headache promptly recurred during the oral administration of 40 mg of prednisolone, 8 days after initial steroid pulse therapy. Sub-Tenon triamcinolone acetonide was injected in both eyes, and serous retinal detachment and headache immediately improved. No recurrence was observed for 8 months until the present, and his best-corrected visual acuity was 0.9 in both eyes. Conclusion: Sub-Tenon triamcinolone acetonide injection may be effective for VKH disease recurrence when added to conventional steroid pulse therapy. This case suggests the possibility of recurrence in the early stage of steroid pulse therapy.




Muto T, Sakamoto M, Machida S, Imaizumi S. Vogt-Koyanagi-Harada Disease Recurred after 8 Days of Initial Steroid Pulse Therapy: A Case Report. Clin Case Rep Int. 2023; 7: 1543.

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