Role of Systemic Inflammation Markers in Colorectal Cancer Prognosis - A Narrative Review

Iaciu CI, Emilescu RA, Cotan HT, Orlov C, Popa AC and Nitipir C

Department of Oncology, Elias Emergency University Hospital, Romania
Department of Medical Oncology, Carol Davila University of Medicine and Pharmacy, Romania
Department of Endocrinology, C.I. Parhon National Institute of Endocrinology, Romania
Department of Endocrinology, Carol Davila University of Medicine and Pharmacy, Romania

^*Correspondance to: Horia-Teodor Cotan 

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Abstract:

Introduction: Systemic inflammation plays an essential role in cancer promotion, progression, and metastasis. The scope of this review is to establish the role of various inflammation-based markers as prognostic tools in Colorectal Cancer (CRC). Methods: A literature search was performed for articles that reported on the prognostic and predictive value of the Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), Lymphocyte-Monocyte Ratio (LMR), and Glasgow Prognostic Score as well as the modified Glasgow Prognostic Score (GPS/mGPS) in relation to CRC. Conclusion: Further prospective studies may result in better risk stratification in patients eligible for curative surgery, limiting the administration of neo-adjuvant and adjuvant therapy to high-risk candidates. In patients with unresectable metastatic disease, inflammation markers can be used as a tool for predicting chemotherapeutic outcomes and monitoring tumor progression.

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Cite the Article:

Iaciu CI, Emilescu RA, Cotan HT, Orlov C, Popa AC, Nitipir C. Role of Systemic Inflammation Markers in Colorectal Cancer Prognosis - A Narrative Review. Clin Case Rep Int. 2023; 7: 1551.