A Rare Cause of Acute Necrotizing Pancreatitis: A Case Report

Matalqah H, Yaseen R, Al-Hajjaj M, Matalkeh L, Matalkeh M and Al Taani B

Orthopedic Surgery, King Abdullah University Hospital, Jordan
Family Medicine, King Abdullah University Hospital, Jordan
Department of Surgery, Aleppo University Hospital, University of Aleppo, Syria
Ministry of Health, Jordan
Jordan University of Science and Technology, Jordan
General Surgery, King Abdullah University Hospital, Jordan

^*Correspondance to: Maher Al-Hajjaj 

 PDF  Full Text Case Report | Open Access

Abstract:

Introduction: Sitagliptin is a class of medications called Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It used to lower blood glucose levels in adults with type 2 diabetes. In rare cases, it may cause acute pancreatitis. Case Report: We report a rare side effect of the administration of sitagliptin in a 47 years old male patient who had diabetes mellitus. He developed acute abdominal pain, nausea, and vomiting after two months of consuming sitagliptin. Abdominal computed tomography showed acute necrotizing pancreatitis. We admitted the patient to the intensive care unit for ten days. Fluid resuscitation and intravenous antibiotics were the definite treatment. Observation for another 20 days in the ward showed a full recovery clinically and laboratory. He had near normal amylase and lipase at home discharge. Follow-up for 12 weeks showed no accidents. Discussion: Acute necrotizing pancreatitis is a fatal condition that really needs emergent diagnosis and treatment. Fluid resuscitation and intravenous antibiotics are the definite treatment. Conclusion: Physicians should suspect acute pancreatitis in patient with abdominal pain and recent use of sitagliptin.

Keywords:

Sitagliptin; Diabetes mellitus; Pancreatitis

Cite the Article:

Matalqah H, Yaseen R, Al-Hajjaj M, Matalkeh L, Matalkeh M, Al Taani B. A Rare Cause of Acute Necrotizing Pancreatitis: A Case Report. Clin Case Rep Int. 2023; 7: 1559.