The Prognostic Role of the Hematological Biomarkers is Questionable in Patients with COVID-19

Karakayalı M, Omar T and Perincek G

Department of Cardiology, School of Medicine, M.D. Kafkas University, Turkey
Department of Cardiology, M.D. Kars Harakani State Hospital, Turkey
Department of Chest Diseases, M.D. Kars Harakani State Hospital, Turkey

^*Correspondance to: Muammer Karakayalı 

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Abstract:

Aim: During the COVID-19 pandemic, hematological biomarkers such as Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), and Neutrophil to Lymphocyte Ratio (NLR) have gained significant attention due to their ready availability, low invasiveness, and quick turnaround time. Reports produced confusing results that were at odds with each other. In this respect, we aimed to more precisely reveal the predictive value of hematological biomarkers in patients with COVID-19. Methods: Demographics, comorbidities, and laboratory results on the admission of hospitalized patients with COVID-19 were analyzed. The study population was divided into two groups according to survival. Findings were compared between survivors and non-survivors. Results: 501 patients with a median age of 60 (IQR, 40-74) were included. The in-hospital mortality rate was 24.5%. A total of 263 (52.5%) patients were male. A higher mortality rate for males and the elderly was observed. Regarding laboratory findings, medians of RDW, MPV, NLR and CRP were significantly higher in non-survivors compared to survivors according to univariate analysis (median (IQR), 14.6 (13.8-16) vs. 13.5 (13-14.6), 10.6 (9.7-11.5) vs. 10.1 (9.4-11), 11.42 (5.74- 22.21) vs. 2.9 (1.82-5.75) and 95.15 (49-162.6) vs. 10.27 (2.3-33.21) all p values <0.05, respectively). However, none of them showed statistical significance in multivariate analysis. According to ROC curve analysis, the diagnostic performance of RDW, MPV, and NLR were lower than CRP. Conclusion: In patients with COVID-19, the relationship between hematological biomarkers and in-hospital mortality is inconsistent. And the predictive role of the hematological biomarkers is questionable.

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Cite the Article:

Karakayalı M, Omar T, Perincek G. The Prognostic Role of the Hematological Biomarkers is Questionable in Patients with COVID-19. Clin Case Rep Int. 2023; 7: 1578.