The Important Role of Dietary Calories in Asthma Pathogenesis

Muyun W, Jieli C, Zhimin T, Zhujun Y, Hao L and Jing C

Department of Medical Oncology, The Fifth People’s Hospital of Wuhu, China
Department of Stomatology, Guangdong Second Traditional Chinese Medicine Hospital, China
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, China
Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, China
Department of Clinical, Guangdong Pharmacy University, China

^*Correspondance to: Cheng Jing 

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Abstract:

Objective: In our previous work, we proposed that dietary calories play an important role in the onset of asthma. To provide further evidence of the importance of calorie reduction in the onset of the disease, we conducted an in-depth analysis on this subject. Data Sources: Our updated analysis was based on our previous research, namely dietary nonallergic factors and atopic diseases, and our 2005 systematic review on calorie-controlled diets for chronic asthma. Study Selections: In our search for articles published between January 2005 and October 2022, we sought directly related Randomized Controlled Trials (RCTs), which assessed the effects of calorie reduction in people with asthma compared to those on conventional diets. Results: A total of 12 articles, with 1,794 patients, were identified and included in our updated calorie control analysis. In addition, some of the articles contained data on the impact of exercise on patients with asthma. The studies involved adults or children with a diagnosis of asthma in general practice or in outpatient departments. In particular, they demonstrated approaches for varying degrees of improvement in asthma symptom control, lung function, and inflammatory markers. Due to heterogeneity and differences among data sets, only Forced Vital Capacity (FVC) (p<0.05), the Asthma Quality of Life Questionnaire (AQLQ) (p=0.002), and the Asthma Control Questionnaire (ACQ) (p=0.00001) could undergo meta-analysis, and yielded significant findings. Conclusion: Our updated analysis highlights the significant role of dietary calorie control in the onset of asthma.

Keywords:

Dietary Nonallergic Factors (DNAF); Mediators; Leukotrienes; Gut-lung Axis; Asthma; Risk Factors

Cite the Article:

Muyun W, Jieli C, Zhimin T, Zhujun Y, Hao L, Jing C. The Important Role of Dietary Calories in Asthma Pathogenesis. Clin Case Rep Int. 2023; 7: 1622.