Desmoplastic Melanoma and Neurofibromatosis Type 1: More Than a Coincidence

Moubine I, Hali F, Diouri M, Marnissi F and Chiheb S
 

Department of Dermatology and Venereology, Ibn Rochd University Hospital, Morocco
Department of Plastic Surgery, Ibn Rochd University Hospital, Morocco
Department of Anatomy Pathology, Ibn Rochd University Hospital, Morocco

^*Correspondance to: Insaf Moubine 

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Abstract:

A 62-year-old man, who was diagnosed with neurofibromatosis type 1 at the age of 30, presented with a nodular lesion on the sole of his right foot. Physical examination revealed a nodular, indurated lesion with a regular pigmented border, located on the inner side of the heel. No lymph node areas showed any signs of involvement, and radiological assessment did not reveal any secondary locations. An initial biopsy of the lesion confirmed the diagnosis of desmoplastic melanoma, leading to subsequent wide tumor resection and sentinel lymph node biopsy. Desmoplastic melanoma is a rare subtype of melanoma that exhibits similar or better survival rates compared to common melanoma of similar thickness. It has been observed that NF1 mutations work in conjunction with oncogenic BRAF mutations to promote melanomagenesis. The frequency of mutations in the NF1 gene in desmoplastic melanoma further strengthens the potential association between neurofibromatosis type 1 and this specific subtype of melanoma.

Keywords:

Desmoplastic melanoma; Neurofibromatosis type 1; NF1 mutation

Cite the Article:

Moubine I, Hali F, Diouri M, Marnissi F, Chiheb S. Desmoplastic Melanoma and Neurofibromatosis Type 1: More Than a Coincidence. Clin Case Rep Int. 2023; 7: 1626.