Genetic Variations in TGF-β1 and MTHFR in Osteoarthritis Patients and Healthy Controls

Vishal C, Ashraf MT, Pramod Y and Vikas R
 

School of Life Sciences and Biotechnology, Chhatrapati Shahu Ji Maharaj University Kanpur, India
School of Biotechnology, Gautam Buddha University, India
Amity Institute of Neuropsychology and Neurosciences, Amity University Uttar Pradesh, India
Madurai Kamaraj University, Tamil Nadu, India

^*Correspondance to: Pramod Yadav 

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Abstract:

Background: The objective of this study was to compare the genomic features of TGF-β1 and MTHFR between patients with Osteoarthritis (OA) and healthy controls in Kanpur, India. Methods: This study collected blood samples from 220 participants, including 100 OA patients and 120 healthy individuals, and analyzed them using genetic polymorphism analysis techniques. The differences in the genetic makeup of TGF-β1 and MTHFR genes between the two groups were determined by using PCR techniques and statical analysis. Results: The results showed significant variations in the expression levels of the TGF-β1 gene in OA patients compared to healthy controls, suggesting its potential role in the pathogenesis of OA. However, the MTHFR 1298A>C SNP was not significantly associated with OA disease in any genetic model, indicating that it is not associated with the pathogenesis of OA. Conclusion: This study highlights the importance of further research to investigate the underlying mechanisms of TGF-β1 and MTHER, and its potential as a therapeutic target for the disease.

Keywords:

Pathogenesis; Therapeutic targets; Genomic comparison; TGF-β1; MTHFR

Cite the Article:

Vishal C, Ashraf MT, Pramod Y, Vikas R. Genetic Variations in TGF-β1 and MTHFR in Osteoarthritis Patients and Healthy Controls. Clin Case Rep Int. 2023; 7: 1637.