Phytochemical Composition, Cytotoxic Effects, and Anti- Inflammatory Capacity of Ethanol Extracts from Erodium Species: E. Glaucophyllum, E. Hirtum and E. Guttatum

Gadhoumi H, Yeddes W, Dakhlaoui S, Hammami M, Bourgou S, Saidani Tounsi M and Hayouni EA

Faculty of Sciences of Tunis, University of Tunis El Manar, Tunisia
Laboratory of Aromatic and Medicinal Plants, Center of Biotechnology at the Ecopark of Borj-cédria, Tunisia

^*Correspondance to: Hamza Gadhoumi 

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Abstract:

Erodium species, native to the southern Mediterranean region, were revered as medicinal herbs celebrated for their numerous health. Polyphenols play a vital role in scavenging free radicals, and numerous health benefits. This study focuses on E. glaucophyllum, E. hirtum, and E. guttatum, aiming to analyze their phytochemical composition, cytotoxic effects, and anti-inflammatory capacity. Total polyphenols, total flavonoids, and condensed tannins content varied significantly among the species and plant parts, with E. glaucophyllum displaying the highest concentrations with 178 ± 4.6 μg GAE/g DR, 80 ± 5 μg RE/g DR, and 40.8 ± 2 μg CE/g DR, respectively. Cytotoxicity assessments revealed dose-dependent effects, indicating generally favorable safety profiles at lower concentrations. E. glaucophyllum exhibited significant cytotoxicity at higher concentrations, emphasizing concentration-dependent effects. The anti-inflammatory potential was evaluated by assessing NO production in murine macrophages, demonstrating dose-dependent reductions for all extracts. E. glaucophyllum exhibited pronounced anti-inflammatory effects, outperforming the reference drug (Vitamin C) at equivalent concentrations. These results position E. glaucophyllum as a promising source of bioactive compounds with notable antioxidant and anti-inflammatory effects, warranting further exploration in natural medicine and drug development.

Keywords:

Medicinal plants; Natural product; Phytochemical composition; Cytotoxic effects; Anti-inflammatory capacity

Cite the Article:

Gadhoumi H, Yeddes W, Dakhlaoui S, Hammami M, Bourgou S, Saidani Tounsi M, et al. Phytochemical Composition, Cytotoxic Effects, and Anti-Inflammatory Capacity of Ethanol Extracts from Erodium Species: E. Glaucophyllum, E. Hirtum and E. Guttatum. Clin Case Rep Int. 2024; 8: 1688..