The Prevalence of Bile Reflux Gastritis Following Cholecystectomy: A Meta-Analysis and Systematic Review

Kitaghenda FK1* and Hidig SM2

1Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, China 2Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, China

^*Correspondance to: Fidele Kakule Kitaghenda 

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Abstract:

Purpose: We reviewed the most current available evidence on the prevalence of bile reflux gastritis following cholecystectomy. Methods: The literature search was performed in PubMed, Google Scholar, and the Cochrane Library database. Results: A total of four studies examining 135 patients were included. The mean age of patients was 54.1 ± 14.53 years. Helicobacter pylori infection was diagnosed in 51 (37.7%) patients preoperatively. The meta-analysis result showed a 49% prevalence of bile reflux gastritis following cholecystectomy at 31 ± 46.80 months postoperatively. Reported digestive symptoms included: Bloating, epigastric pain, heartburn, gastroesophageal disease, belching, stomach fullness, and vomiting. Furthermore, gastric endoscopic findings were: Chronic inflammation of gastric mucosa, neutrophil activation, glandular atrophic gastritis, bile stasis, edema, and fovea hyperplasia. Conclusion: The prevalence of bile reflux gastritis after therapeutic cholecystectomy is high. The presence of gastrointestinal symptoms should prompt the consideration of bile reflux gastritis as a potential etiology.

Keywords:

Bile reflux gastritis; Cholecystectomy; Gastritis; Gallbladder; Alkaline reflux

Cite the Article:

Kitaghenda FK, Hidig SM. The Prevalence of Bile Reflux Gastritis Following Cholecystectomy: A Meta- Analysis and Systematic Review. Clin Case Rep Int. 2024; 8: 1706..