Aplastic Anaemia with RTEL1 Mutation Combined with Hepatocellular Adenoma: A Case Report and Literature Review

Gao Jingchen, Liu Haiyan, Yang Hui, Feng Ye, Qin Jiebin and Wen Xianhao*

Department of Hematology and Oncology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China

^*Correspondance to: Wen Xianhao 

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Abstract:

Aplastic Anaemia (AA) is a disease characterized by failure of the bone marrow. Androgens can be used to treat AA by controlling telomerase activity and promoting haematopoiesis in the bone marrow. Hepatocellular adenomas are benign tumours of the liver associated with the use of oral contraceptives and androgen therapy. Here, we report a case of aplastic anaemia patient with RTEL1 mutation and hepatocellular adenoma. The tumour reduced in size after embolisation, and it was resected because of rupture and haemorrhage. Androgens are used to treat AA, and some androgens can cause hepatocellular adenomas. Therefore, symptoms should be recognised early, and appropriate early treatment should be administered.

Keywords:

Aplastic anaemia; Hepatocellular adenoma; Androgens; RTEL1

Cite the Article:

Jingchen G, Haiyan L, Hui Y, Ye F, Jiebin Q, Xianhao W. Aplastic Anaemia with RTEL1 Mutation Combined with Hepatocellular Adenoma: A Case Report and Literature Review. Clin Case Rep Int. 2024; 8: 1707..