Red Deer Umbilical Cord Lining Mesenchymal Stem Cell Conditioned Media after Monopolar Radiofrequency Facial Treatment – A Case Series

Dissapong Panithaporn*, Punnapath Buranasirin and Papatsara Asavaphark

The Demis Clinic, Bangkok, Thailand

^*Correspondance to: Dissapong Panithaporn 

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Abstract:

Background: Monopolar radiofrequency (MRF) is a valuable non-ablative modality to treat mildto- moderate skin laxity and wrinkles. As maximum MRF results are only achieved months after treatment, there is ongoing interest in enhancing efficacy. Objective: To assess the effect of a serum containing Red Deer Umbilical Cord Lining Mesenchymal Stem Cell conditioned media (RD-CLMSC-CM) on skin rejuvenation outcomes after MRF. Methods: Ten adults (30-64 years) with a clinical need for a facelift, based on the presence of mild to severe facial wrinkles, were treated with MRF. Afterwards, moisturizer was applied to the entire face. RD-CLMSC-CM was applied to the right half of the face, twice daily (morning and evening) for four weeks. QuantifiCare analysis was performed at baseline and 2, 4, 6, and 8 weeks. Results: The difference between the intervention side and the control side was minimal at week 2. By week 4, however, the mean difference reached statistical significance (p = 0.004), which persisted through week 6 (p = 0.021) and week 8 (p = 0.019), consistently favoring the intervention side. On the intervention side, facial lifting improved significantly at weeks 4, 6 and 8, compared to week 2, while the control side did not show a significant improvement between week 2 and week 4. Conclusions: This case series suggests that MRF combined with RD-CLMSC-CM serum may provide favorable clinical outcomes. These findings provide support for setting up randomized, controlled clinical trials to better assess the efficacy of RD-CLMSC-CM.

Keywords:

Calecim, Mesenchymal stem cells, MSC-CM, MSC-derived conditioned media, Stem cells, Monopolar radiofrequency, Skin tightening

Cite the Article:

Panithaporn D, Buranasirin P, Asavaphark P. Red Deer Umbilical Cord Lining Mesenchymal Stem Cell Conditioned Media after Monopolar Radiofrequency Facial Treatment – A Case Series. Clin Case Rep Int. 2025; 9: 1721..