Leptomeningeal Carcinomatosis as Primary Presentation in Gastrointestinal (Gi) Malignancies- Case Series and Review of Literature

Shivangi Vikas Mishra1, Sambit Dash2, Deepali Mathur2,3* and Bikash Kumar Mishra2,3

IMS and SUM hospital, Bhubaneswar, Odisha, India Department of Neurology, Apollo Hospitals, Bhubaneswar, Odisha, India Neuro Care Centre, Bhubaneswar, Odisha, India

^*Correspondance to: Deepali Mathur, Bikash Kumar Mishra 

 PDF  Full Text Case Series | Open Access

Abstract:

Background: Leptomeningeal Carcinomatosis (LC) is a serious complication of cancer where the malignant cells spread to the meninges of Central Nervous System (CNS) involving the pia mater and arachnoid mater. LC heralds a poor prognosis with limited treatment options. 
Case Presentation: We intend to report three cases of LC which is commonly the secondary event to Gastrointestinal (GI) malignancies and is very rare to be the presenting symptom. We present case series of three patients diagnosed with LC. Clinical  examination of Case 1 revealed that he had left hemiparesis. Case 2 had neck rigidity with no other focal deficit. Upper GI endoscopy of Case 2 revealed ulcerated lesion in stomach and biopsy revealed infiltrating adenocarcinoma of stomach.
Case 3 revealed cerebellar signs on clinical examination. 
Conclusion: LC is a less commonmanifestationand is rare tobe the presenting symptoms. Prudent and detailed evaluation is mandatory.

Keywords:

Leptomeningeal carcinomatosis; Gastrointestinal malignancies; Magnetic resonance
imaging; Histopathology; Clinical examination

Cite the Article:

Mishra SV, Dash S, Mathur D, Mishra BK. Leptomeningeal Carcinomatosis as Primary Presentation in Gastrointestinal (GI) Malignancies - Case Series and Review of Literature. Clin Case Rep Int. 2025; 9: 1731.