Etanercept Treatment as a Predisposing Factor for Acute Liver Injury Caused by HEV Infection - A Case Report

Kowalski M*, Niksińska A, Tłustochowicz W and Przybyłkowski A

Department of Gastroenterology and Internal Diseases, Medical University of Warsaw, Poland
Department of Rheumatology and Internal Diseases, Military Institute of Warsaw, Poland

^*Correspondance to: Kowalski M 

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Abstract:

We report a case of a 58-year-old patient with rheumatoid arthritis treated with Methotrexate (Mtx) and etanercept, who developed a sudden elevation of the liver enzymes during routine monitoring. Initial workup excluded common causes of hepatotoxicity. Further evaluation revealed acute Hepatitis E Virus (HEV) infection. Immunosuppressive therapy may have contributed to the atypical presentation. Transaminase activity levels nearly normalized after a short course of prednisone therapy. This case highlights the importance of considering HEV infection in immunosuppressed patients presenting with unexplained hepatic enzyme elevation.

Keywords:

Hepatitis E virus; Etanercept treatment; Liver injury; Hepatotoxicity

Cite the Article:

Kowalski M, Niksińska A, Tłustochowicz W, Przybyłkowski A. Etanercept Treatment as a Predisposing Factor for Acute Liver Injury Caused by HEV Infection - A Case Report. Clin Case Rep Int. 2025; 9: 1747..