Focal Segmental Glomerulosclerosis in Systemic Lupus Erythematosus

Baris Eser, Alpaslan Karabulut, Ibrahim Dogan and Aysel Colak

Department of Internal Medicine, Hitit University, Erol Olcok Training and Research Hospital, Turkey
Department of Nephrology, Hitit University, Erol Olcok Training and Research Hospital, Turkey
Department of Pathology, Ankara Numune Training and Research Hospital, Turkey

^*Correspondance to: Baris Eser 

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Abstract:

Nephrotic syndrome is a common presentation of lupus nephritis. In patient with Systemic Lupus Erythematosus (SLE) and the nephrotic syndrome, the two most common renal biopsy findings are diffuse proliferative lupus nephritis [World Health Organization (WHO) class IV] and membranous lupus nephritis (WHO class V). Lupus nephritis is divided into 6 distinct morphologic classes according to WHO. On the other hand non-lupus nephritis in patient with confirmed SLE is rarely reported. The relevant glomeruler lesions most frequently defined are amyloidois and Focal Segmental Glomerulo Sclerosis (FSGS). Thirty-six year-old female patients admitted with acute renal damage and nephrotic syndrome clinical findings. She fulfilled the following criteria of the American College of Rheumatology for SLE diagnosis: positive anti-dsDNA and ANA, leukopenia and cutaneous maculea. FSGS was detected in kidney biopsy. We believe that the patient had SLE and developed FSGS and we believe that lupus nephritis needs new classification.

Keywords:

Acute kidney damage; Focal segmental glomerulosclerosis; Systemic lupus erythematosus

Cite the Article:

Eser B, Karabulut A, Dogan I, Colak A. Focal Segmental Glomerulosclerosis in Systemic Lupus Erythematosus. Clin Case Rep Int. 2018; 2: 1075.