Journal Basic Info

  • Impact Factor: 0.285**
  • H-Index: 6
  • ISSN: 2638-4558
  • DOI: 10.25107/2638-4558
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Sleep Medicine and Disorders
  •  Neonatology
  •  Gastric Cancer
  •  Ophthalmology
  •  Hepatology
  •  Urology Cases
  •  Allergy & Immunology
  •  Nursing


Citation: Clin Case Rep Int. 2020;4(1):1160.DOI: 10.25107/2638-4558.1160

Precocious Puberty Induced by a Pilocytic Astrocytoma in a Boy

Rosa Finozzi, Beatriz Mendoza, Camila Keosseian, Mariana Risso and Alvaro Ronco

Department of Endocrinology and Metabolism, University of the Republic, Uruguay Department of Oncology and Radiotherapy, Pereira Rossell Hospital, Uruguay

*Correspondance to: Rosa Finozzi 

 PDF  Full Text Case Study | Open Access


The incidence of central isosexual Precocious Puberty (PP) in males is low. Its most frequent cause is an organic one. We herewith present the case of an 8-year-old male patient with a tumor-induced PP caused by a pilocytic astrocytoma. Very few cases of this tumor type have been reported in the medical literature as a cause of PP. The Magnetic Resonance Imaging showed a mass displacing and compressing the III ventricle and the optic chiasm. The mass extended to the middle cranial fossa causing a dilation of the lateral ventricles. A male patient bearing a central PP should lead us to think of a Central Nervous System (CNS) tumor. Tumors affecting the CNS particularly those affecting the hypothalamic region- can express themselves as puberty disorders. In this case we highlight the remarkable reversal of the secondary sexual characteristics following the excision of the tumor, as well as the patient’s seven year survival.


Precocious puberty; CNS; FSH; Pilocytic astrocytoma

Cite the Article:

Finozzi R, Mendoza B, Keosseian C, Risso M, Ronco A. Precocious Puberty Induced by a Pilocytic Astrocytoma in a Boy. Clin Case Rep Int. 2020; 4: 1160.

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