Journal Basic Info

  • Impact Factor: 0.285**
  • H-Index: 6
  • ISSN: 2638-4558
  • DOI: 10.25107/2638-4558
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Surgery
  •  Neurology
  •  Psychiatry
  •  Leukemia¬†
  •  Sleep Medicine and Disorders
  •  Physical Medicine & Rehabilitation
  •  Obstetrics and Gynecology
  •  Transplantation Medicine

Abstract

Citation: Clin Case Rep Int. 2022;6(1):1389.DOI: 10.25107/2638-4558.1389

Mismatch Repair Status Analysis on Endometrial Biopsy as a Predictor of Endometrial Cancer Behavior in Fertility Sparing Treated Women

Capasso I, Perrone E, Scambia G and Fanfani F

Department for Women's and Child Health and Public Health, A. Gemelli University Hospital Foundation, Italy
Catholic University of Sacred Heart, Italy

*Correspondance to: Emanuele Perrone 

 PDF  Full Text Case Report | Open Access

Abstract:

Conservative management for patients with mucosal-confined endometrial cancer is a safe approach. Due to the latest evidences, endometrial cancer molecular characterization results crucial for proper risk stratification. A young woman with G1 endometrioid endometrial cancer diagnosed by hysteroscopy was treated conservatively. After cancer persistence, she underwent radical surgery for advanced disease. Posthoc immunohistochemical analysis was performed comparing the first-diagnosis biopsy (mismatch repair deficiency) to surgical specimen (mismatch repair proficiency). Interestingly, not only the cancer changed biochemically, but it also shifted from a confined tumor to an advanced disease with bulky lymph nodes and negative endometrial infiltration. Eventually, the patient was diagnosed with Lynch syndrome. A wiser evaluation of the mismatch repair deficiency should have guided to the proper therapeutic algorithm, also suggesting genetic tests. This case report represents an encouragement to further investigations on molecular assessment as a predictor for endometrial cancer risk stratification in conservative management.

Keywords:

Cancer; Endometrium; Fertility; Genital Neoplasms; Immunohistochemistry

Cite the Article:

Capasso I, Perrone E, Scambia G, Fanfani F. Mismatch Repair Status Analysis on Endometrial Biopsy as a Predictor of Endometrial Cancer Behavior in Fertility Sparing Treated Women. Clin Case Rep Int. 2022; 6: 1389.

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