Human Immunodeficiency Virus-Negative Plasmablastic Lymphoma: A Case Report and Literature Review

Liu Jianmin, Deng Renfang, Li Jiwei

Department of Oncology, The Second Hospital of Zhuzhou City, China
Department of Oncology, The Second Xiangya Hospital, Central South University, China
These authors contribute equally to this work

^*Correspondance to: Ji-Wei Li 

 PDF  Full Text Case Report | Open Access

Abstract:

Introduction: Plasmablastic lymphoma is a rare subtype of B cell lymphoma with poor prognosis. The pathogenesis and molecular features of this rare entity was largely unclear. Case Report: We report a rare case of PBL in a 57-year-old immunocompetent male patient. The patient was admitted to our hospital because of multiple lymph node enlargement detected by computed tomography during the physical examination. The biopsy results confirmed the diagnosis of PBL. This patient achieved partial remission after DA-EPOCH chemotherapy and received ASCT as consolidation therapy. However, disease progression occurred and the patient died 2 months after ASCT. Discussion: PBL is characterized by rapid disease progression and high mortality rates. More effective treatment regimen needs to be explored. Conclusion: PBL was a highly invasive rare lymphoma with poor prognosis, it is urgent to develop new targets and agents.

Keywords:

Plasmablastic lymphoma; HIV; ASCT

Cite the Article:

Liu JM, Deng RF, Li JW. Human Immunodeficiency Virus-Negative Plasmablastic Lymphoma: A Case Report and Literature Review. Clin Case Rep Int. 2023; 7: 1605.