Parkinsonism, a Sequel of Severe Self-Induced Methanol Poisoning

Herishanu YO, Merkin E and Shelef Y
 

Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Israel
Department of Radiology, Soroka University Medical Center, Ben-Gurion University of the Negev, Israel

^*Correspondance to: Yuval O Herishanu 

 PDF  Full Text Case Report | Open Access

Abstract:

Acute methanol poisoning occurs sometimes in people who cannot afford the prices of marketed alcoholic beverages and utilize methanol as a substitute, in those who deliberately try to commit suicide, or in people using methanol for their work, like those working in the laboratories etc. The clinical picture of the acute methanol poisoning consists of a tetrad of symptoms: Optic and central nervous system, gastrointestinal and respiratory tract symptoms. These symptoms are an expression of developing metabolic acidosis due to methanol metabolites (formate). Optic nerve damage leads in a majority of the cases to loss of vision and optic nerve atrophy. Late sequelae in the patients who survive severe intoxication, beside blindness, include parkinsonism. We present here the clinical picture in a patient who suffered a severe methanol intoxication after a suicidal attempt, who after recovery from the acute intoxication developed a parkinsonian akinetic syndrome responsive to I-DOPA. In this case CT of the brain was normal, although MRI of the brain disclosed bilateral putaminal necrosis with some other unusual features.

Keywords:

#

Cite the Article:

Herishanu YO, Merkin E, Shelef Y. Parkinsonism, a Sequel of Severe Self- Induced Methanol Poisoning. Clin Case Rep Int. 2024; 8: 1676.