Infliximab for Cutaneous Vasculitis with Double Negative ANCA and Vessel Wall Biopsy: A Case Report

Li-Feng Chen*, Yi-Qing Feng and Juan Ni

Department of Rheumatology and Immunology, General Hospital of Central Theater Command, Wuhan, China Deaprtment of Internal Medicine, Hubei University of Medicine, China

^*Correspondance to: Li-Feng Chen 

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Abstract:

Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a necrotizing granulomatous vasculitis that affects small arteries, veins, and capillaries throughout the body. It is frequently associated with Antineutrophil Cytoplasmic Antibodies (ANCA). However, we found that a 60-year-old male with ANCA-negative and pathological changes in the vessel wall was not obvious, which still met the diagnostic criteria for GPA. The patient was not definitively diagnosed at the first visit, and after treatment with Chinese herbal medicine,a series of debridement surgeries, and antibiotics, the lesions did not improve, and the wound was enlarged. The patient was then transferred to our department, where anti-inflammatory treatment was initiated. After one month, the lesions remained unhealed. We then added infliximab to the patient's subsequent treatment. Surprisingly, the wound showed a healing trend after the treatment regimen was changed, which has potential clinical relevance for GPA present on the skin only.

Keywords:

Granulomatosis with Polyangiitis, Vasculitis, Infliximab, Immunosuppressive agents

Cite the Article:

Chen L-F, Feng Y-Q, Ni J. Infliximab for Cutaneous Vasculitis with Double Negative ANCA and Vessel Wall Biopsy: A Case Report. Clin Case Rep Int. 2025; 9: 1724..