Chronic Kidney Disease as a Progressive Long-Term Sequela of Thrombotic Thrombocytopenic Purpura: A Case Report

Abdelrahman Shehata*, Juhena Shaikh, Ayisha Shahila Jasmin, Mohammed Mustafa Khan, Izzah Tamseel Khanum and Hind Hassan Al Nour
 

College of Medicine, Gulf Medical University, Ajman, UAE
Nephrology Department, Dubai Hospital, Dubai, UAE

^*Correspondance to: Abdelrahman Shehata 

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Abstract:

The case report describes a 39-year-old male patient who has Chronic Kidney Disease (CKD) stage 3b as a sequela of Thrombotic Thrombocytopenic Purpura (TTP). He was diagnosed in 2014. The patient had positive negative ADAMTS13 activity and biopsy-proven TTP. He did not respond to hypertensive emergency and microangiopathic hemolytic anemia. The acute management was comprised of the continuous veno-venous hemodiafiltration, plasmapheresis, rituximab and methylprednisolone. After 11 years’ follow-up, the renal function reached the level of CKD 3b with an estimated glomerular filtration rate of 40 mL/min/1.73m2, whereas hypertension was treated by multidrug therapy. The assessment carried out recently showed no active symptoms and controlled blood pressure. This report highlights the possibility of long-term renal impairment after resolving TTP and suggests the use of long-term multidisciplinary monitoring.

Keywords:

Thrombotic Thrombocytopenic Purpura (TTP); Chronic Kidney Disease (CKD); Thrombotic Microangiopathy; ADAMTS13 deficiency; Acute Kidney Injury (AKI)

Cite the Article:

Shehata A, Shaikh J, Jasmin AS, Khan MM, Khanum IT, Al Nour HH. Chronic Kidney Disease as a Progressive Long-Term Sequela of Thrombotic Thrombocytopenic Purpura: A Case Report. Clin Case Rep Int. 2026; 10: 1771.